Toepler Medical Research és Neuropsichology Test Center

H-5000 Szolnok, Baross utca 49-51 Földszint

Toepler Institute (short description)

In memoriam Dr.Töpler Károly Ágost / Dr.Toepler, Joannes, Carolus Augustus /

Dr. Toepler Károly Ágost / Dr. Toepler, Joannes, Carolus Augustus / obstetrician, one of the ordinary chief physicians of the city of Sopron, Budapest Hungarian Royal Student of the Society of Natural Sciences, Vienna Corresponding member of K. Medical Association

born Sopron 1798, died Gyalóka 1850

Dr. Károly Ágost Toepler was born in Sopron in 1798 to Gottlieb Toepler and Katalin Német. The family’s name is Toepler in German-language documents, while in Hungarian-language documents It is written as Töpler. The Toepler family settled in Sopron from Germany in the 17th century. The family is listed in the Sopron civil registry it is mentioned for the first time in 1698, after Toepler Gottfried who received citizenship as a baize maker on 16.06.1698.

His father, Christoph Toepler, is mentioned in these documents as a gardener in Zwölfhuben. The evangelist marital records state that, Christoph was a merchant in Marglissa in Ober-Lausnitz. According to the civil register of Sopron, Toepler Gottfried was originally from Debnitsch in Ober-Lausnitz, while the council according to the protocol, he comes from Schedewahl. Gottlieb Toepler was an external councilor for the city of Sopron, thus Among other things, he was responsible for the hygiene rules, which are of great from the point of view of the city monitoring compliance at the homes of city residents. Dr.Toepler, Joannes, Carolus as Dr. Károly Ágost Töpler received citizenship in Sopron on 14.08.1833, and from 1838 he became the city’s outer advisor. *1

Dr.Károly Ágost Toepler graduated from the University of Vienna on 07.06.1823. Toepler, Joannes, the title of Carolus Augustus’s medical dissertation is : quot; Dissertatio inauguralis philosophico-medica de ratione et experientia, duobus medicinae fundamentis. 7. junii 1823, Vindobonae 1823 typis J.E. Akkermann, VIII, 40 p. His dissertation, recommended for friends, colleagues and medical students who want more knowledge, is presented in the he wrote of reason and experience, the two foundations of medicine.* 2

In the 1840s, in the nascent Hungarian academic life, dr. Töpler was a regular member of the Society of Hungarian Medical Doctors and Natural Scientists. In 1847, he was one of the main speaker and secretary of an internationally outstanding scientific event held by the Medical Society in Sopron.

The speakers and topics of the medical lectures of the MOTT Sopron Wandering Assembly were as follows *5:

  1. Dr. János Sándorffy – Sopron county description
  2. Dr. Ágost Károly Töpler – Autopsies
  3. Dr. János Gárdos – About spiritism, that is, about animal magnetism
  4. Dr. Antal Eisenstein – About sleepwalking and its causes
  5. Dr. Dániel Wágner – Medicinal chemistry thesis on artificial mineral waters
  6. Dr. Mihály Viszanik – An outline of soul medicine
  7. Dr. Ferenc Bene (junior) – Sketches taken from the field of psychiatry (Lecture on European lunatics)

It was during this presentation that the establishment of the Hungarian National Mental Health Center was formulated for the first time the necessity of the Hungarian head of the lunatic asylum in Vienna, University Professor György Majsisovits for personal speech.

Based on the protocol of the medical-surgeon department, the following official description was prepared:

  1. A) Minutes: Ferenc Bene, János Sándorffy Vice Presidents, Endre Kovács Sebestyén and József Hankó


  1. B) Theses:
  2. Description of Sopron county: János Sándorffy, chief physician of Sopron county
  3. On sleepwalking and its causes: Eisenstein, University teacher, Vienna
  4. On spiritualism, i.e. animal magnetism: János Gárdos, University teacher, Vienna
  5. Autopsies: Ágost Károly Töpler, Chief Medical Officer of the city of Sopron

Renowned international speakers of the medical department were:

  • Wattman, University professor, Vienna
  • Dr. György Majsisovits, University professor, Vienna
  • Mihály Visanik, University professor, Vienna
  • Granishtatten, Chief Medical Officer of the City of Vienna
  • Fink, Chief Field Physician, Vienna


Family and descendants

Dr.Toepler Károly Ágost was married to Martiny Ludovika, whom he had six children with. Charles, Alexander, Otto, Emma, Luise and Irma.

The descendants of Dr.Károly Ágost Toepler who were working on the medical field, without completeness:

Dr. Károly Toepler, (son, b. 1826 an: Martiny Ludovika ) general surgeon, Sopron

Dr. István Péter (grandson, b. 1957 mother: Judit Toepler) veterinarian, chief veterinary officer of J-N-Sz County, Hungary Agriculture was Atasseya USA

Judit Péter, (granddaughter, sz:1970 mother: Judit Toepler), psychologist, SOTE Department of Neurology, clinical psychologist, neuropsychologist, Toepler MRC-TRC

Emma Buczkó, (descendant by mother: Judit Péter), VI. year medica, PTE

The descendants of Dr.Károly Ágost Toepler, who studied law:

Dr.Kálmán Toepler, (grandson: ) judge, Mayor of Sopron

Dr. Károly Ágost Toepler biographical material written and complied by István Buczkó doctor, Toepler MRC-TRC institute Head

Departments of Toepler Institute

Scientific Research Groups

Neurocognitive Changes in Obstructive Sleep Apnea

The aim of our research is to investigate cognitive functions in obstructive sleep apnea syndrome (OSA) compared to a control group without sleep disorders, adapted in age, gender and education. At the beginning of the study, all participants undergo a pre-screening, during which they are required to complete paper-based questionnaires regarding somnolence (Epworth Somnolence Scale) and the presence of OSA symptoms (Berlin Questionnaire).

People who receive a negative rating at the pre-screening, so they do not have sleep apnea, are placed in the control group and we take the psychometric test we have compiled with them. People who receive a positive rating based on the paper pre-screening, so there is a suspicion of OSA, will undergo an additional all-night polygraphy measurement by the sleep lab. If the polygraphy examination confirms OSA based on the opinion of the somnologist, these individuals will undergo an additional full-night polysomnography examination at the sleep laboratory. Based on the result of the latter, the somnologist makes the diagnosis and forms groups based on the severity of the symptoms: mild, moderate and severe OSA.

For individuals with a severe degree of OSA, an additional sleep laboratory test, the Maintenance of Wakefulness Test (MWT), is performed to map somnolence, its overcoming, and wakefulness stability. Additionally, persons who are recommended to undergo therapeutic treatment from all three severity categories are determined. In the case of the OSA group, a test batterie measuring neurocognitive functions is taken after the polysomnographic examination, before the start of therapeutic treatment. The inclusion of the test package is planned to be repeated before the start of treatment and after 6 and 12 months after treatment, to follow up on possible neurocognitive changes due to therapy. Sleep apnea patients who do not undertake therapeutic treatment after diagnosis are a separate group and we plan to follow them up. The tests have a similar structure but include different tasks to avoid the learning effect. The planned duration of the study is 3 years, after 12 months we collect information annually in the form of a questionnaire on the occurrence of a work accident and a road accident. Based on the literature history, we expect that the OSA group will show a cognitive deficit compared to the control group. As a result of the therapy, we expect significant improvements in sleep patterns, breathing during sleep, and cognitive functioning.

In addition, our goal is to compile a psychometric test package measuring neurocognitive functions that may be suitable for OSA patients, to prepare an opinion on the suitability to perform activities with a high risk of accidents, and to determine the minimum conditions for neuropsychological status (e.g. road driving license, lifting imaging license medical fitness assessment).

Dr. Csábi Eszter PhD  

research lead psychologist; assistant professor

Dr. Buczkó István

Head of institution, head of research center;
general and occupational medicine
specialist, qualified health manager

Dr. Kunos László PhD

research pulmonologist, somnologist

Péter Judit

researcher Clinical and Mental Health Psychologist;
candidate neuro-psychologist

Mochnács Fanni

researcher psychologist

Sipos Viktória

sleep technician

Vidinszki Zsolt


Szűcs Zsuzsanna

administration manager

Buczkó Emma

researcher, medical student at PTE

Scientific Service Units

Sleep laboratory


  • Home respiratory polygraphy (PG)
  • Polysomnography testing (PSG) in the sleep laboratory
  • Complex Sleep Diagnostic Examination and neuropsychological testing (PSG + Psychology Tests)
  • Maintenance of Wakefulness Testing in the sleep lab (MWT)
  • Multiple Sleep Latency Test in the sleep lab (MSLT)
  • Continuous Positive Airway Pressure (CPAP) machine titration

Testing Equipment

  • Polysomnography (PSG) SOMNO HD TM (EEG/EOG) –M1,M1.EOGL,EOGR,F4,F3,C4,C3,O1,O2,REF,GND,EMG REF, EMG+, EMG monitoring ability)
  • Polysomnography (PSG) SOMNO TOUCH TM (EMG, EOG, C3, O1, GND, CZ, F3, A2 monitoring ability)
  • Polygraphy (PG) ResMed Apnea Link Air home respiratory polygraphy device (2 devices)
  • Thermography Scan
  • CardioMera (24hr Ambulatory Holter ECG monitoring system)
  • CardioTens (24hr Ambulatory blood pressure and ECG monitoring system)
  • ABPM 05 (Ambulatory Blood Pressure Monitoring System)

Supplementary Testing Equipment

  • ECG, Audiometer, Incentive Spirometer
  • Thermography Scan

Psychology Lab

Psychological Examinations

  • VTS – Measurement of visual-spatial orientation (Hungarian norm examination in progress)
  • VTS – Short-term space and working memory capacity measurement (Hungarian norm testing in progress)
  • VTS – Figural learning performance and figural episodic memory (Hungarian norm testing in progress)
  • VTS – Assessment of mental abilities, cognitive flexibility (Hungarian norm examination in progress)
  • VTS – Visual orientation measurement (Hungarian norm testing in progress)
  • VTS – Verbal working memory (Hungarian norm testing in progress)
  • VTS – Assessment of general neuropsychological abilities: attention, speed of visuomotor processing and executive functions (Hungarian norm testing in progress)
  • VTS – Measurement of attention subfunctions (Hungarian norm testing in progress)
  • Distributive attention test (own norm, previously collected)
  • Complex sensomotorial tester (own norm, previously collected)
  • Personality profile (own norm, previously collected)
  • Maintenance of Wakefulness Testing (MWT) in the sleep lab (hungarian norm developed, 2017. EüK. 16. number, based on EMMI professional guidelines)
  • Multiple Sleep Latency Test (MSLT) in the sleep lab (hungarian norm developed, 2017. EüK. 16. number, based on professional EMMI guidelines)

Psychology Lab Equipments

Our main equipment:
  • Vienna Test System (Schuhfried GmbH)
  • Polysomnography (PSG) SOMNO HD TM with (EEG/EOG) –M1, M1. EOGL, EOGR, F4, F3, C4, C3, O1, O2, REF, GND, EMG REF, EMG+, EMG monitoring ability
Supplementary Testing Equipment:
  • Pieron Attention Test (Bánsági Péter)
  • Minnesota Multiphasic Personality Test –MMPI-2- (OS Hungary Kft.)
Professional Staff

Kunos László PhD  – researcher pulmonologist, somnoligist
Buczkó István – research manager, head of research unit; General Practitioner, Occupational Medical Doctor, Health and Work Safety Specialist
Buczkó Emma – researcher, medical student at PTE
Körmöndi Hajnalka – trained ambulatory nurse
Sipos Viktória – sleep technician
Szécsi Boglárka – trained ambulatory nurse
Csábi Eszter PhD – lead researcher psychologist, researcher, and university professor
Péter Judit MA – researcher, Clinical psychologist, neuropsychologist
Mochnács Fanni MA – researcher, testing manager psychologist

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